Hair Genesis? Experience The Power Of Science
advent of topically delivered minoxidil (Rogaine) in the early to
mid 1980's demonstrated for the first time that pharmacological
treatment of pattern hair loss was a viable option. In the early
1990's the development of orally administered finasteride (Propecia)
showed that a systemically focused 5AR (5-alpha reductase) blockade
was also a realistic target for the purpose of arresting hair loss.
Importantly, this drug established a basis for the systemic use
of a 5AR inhibitor against pattern
hair loss. You may recall that 5AR has been strongly implicated
in precipitating the hormonal processes linked to pattern hair loss
also known as androgenetic alopecia (AGA). Order
The next evolutionary
step in this process was our recognition that botanically derived
molecules may offer a number of compelling advantages over pharmaceutically
based alternatives. In fact, we were the first to market botanically
based hair loss
treatment formulations beginning in 1996. In the past several
years a great deal of research has been directed toward the examination
of a number of naturally educed substances, specifically those which
have shown the ability to inhibit 5AR. The most widely researched
substance of this kind is the liposterolic extract of saw palmetto
(LSESr). Historically, this botanical earned an excellent track
record of success against BPH (benign prostatic hyperplasia), a
prostate disorder linked with the same metabolic changes evident
tested this substance against pharmaceutical compounds such as minoxidil
and finasteride (ref). They found that it compared very favorably
in a number of relevant lab assays, particularly those involving
the inhibition of 5AR. In one research
study it was shown that LSESr was a 3-fold more efficient inhibitor
of this problematic enzyme than the drug finasteride.
recognized botanicals such as grape seed extract, borage oil, evening
primrose oil, and others, have also shown promising activity against
the changes associated with AGA. It is our hypothesis that a number
of these botanical tools may offer greater efficacy when combined
together, in contrast to any one substance utilized alone.
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In our laboratory,
we have advanced this early research
in several ways. Now, we have developed a
new generation of oral and topical formulas based heavily around
these novel extracts. Further, we have examined one new generation
formula in particular in a placebo-controlled, double-blind clinical
trial. A manuscript detailing results from this study has
been submitted for publication within a peer-reviewed scientific
journal and is currently under editorial review. We continue
to examine novel botanical molecules in an effort to harness them
as new weapons against AGA.
Botanicals offer a
powerful set of tools in the treatment of pattern hair loss.
In the coming years ahead, we may anticipate the development of
ever more efficacious treatment options based on this paradigm.
Our goal is to continue to provide our valued clients with the most
scientifically advanced product line to combat hair loss.
Dr. Geno Marcovici
Chief Scientific Officer
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